Current Research

The Early Psychosis: Investigating Cognition (EPIC) study makes use of functional Magnetic Resonance Spectroscopy (fMRS) to examine real time changes in brain metabolites to study cognitive dysfunction in psychosis.

The clinical and cost-effectiveness of Stimulant compared with Non-stimulant medication for adults with Attention-deficit/hyperactivity disorder and a history of Psychosis or biPolar disordER

Clinical effectiveness and implementation evaluation of the Early Psychosis Informatics into Care [EPICare] digital psychosis register and clinical decision support system.

EPICare is a national project developing a digital dashboard and patient registry to help Early Intervention in Psychosis teams track care, treatment and recovery outcomes in real time.

HeatMAP (Heat-related gut-Microbiota-brain-Axis changes in Psychosis) is an international study exploring how heat-related changes in the gut-microbiota-brain axis may contribute to new or relapse of psychosis.

This MRC-funded programme is developing personalised, non-invasive brain stimulation treatments to improve difficult-to-treat symptoms, cognitive function and quality of life across a range of psychiatric and neurological conditions.

This study will investigate whether temporal interference stimulation can prime deeper brain regions to enhance the effects of transcranial magnetic stimulation, supporting the development of more effective, multi-target neuromodulation treatments for depression.

ADEPP investigates whether the antidepressant sertraline could prevent depression and support recovery in people following their first episode of psychosis.

Women having her brain scanned by a TMS figure of 8 tool — Source: Institute Dual Stim Laboratory and credit photo by Alex Wilkinson

TRIDENT (Theta buRst stImulation for aDolescent dEpressioN feasibiliTy study) is an NIHR-funded feasibility study exploring whether intermittent theta burst stimulation, a short form of transcranial magnetic stimulation, could be a practical and acceptable treatment option for adolescents with depression.

The HOME Study is a national trial exploring whether home-based transcranial direct current stimulation can help improve symptoms of depression alongside usual care.

UniCog is an online automated cognitive assessment battery designed for people of all language, cultural and educational backgrounds to provide a fairer and more accessible way to assess cognitive functions.

The SMILE BioResource is a national initiative creating a re-contactable research resource of volunteers with severe mental illness to support future studies into the causes, symptoms and treatment of psychosis and related conditions.

As part of a European project, we will develop and validate computational models to predict the effects of brain stimulation, may it be magnetic (Transcranial Magnetic Stimulation, TMS), electric (Deep Brain Stimulation, DBS), or ultrasound stimulation (US).

Centre for

Translational Neuroscience

EPIC: Early Psychosis – Investigating Cognition

SNAPPER: an ADHD and Psychosis/Bipolar disorder trial

EPICare: Improving outcomes for people with psychosis through better data and analysis

HeatMAP: Role of heat related gut-microbiota-brain-axis changes in psychosis

MRC-Programme: Closed-loop non-invasive stimulation for improving brain and mental health

TITAN-D: Temporal Interference Targeted Augmentation of Neuromodulation for Depression - BRC Innovation Fund 2025

ADEPP: Antidepressant For The Prevention Of DEPression Following First Episode Psychosis Trial

TRIDENT: Theta burst stimulation for adolescent depression feasibility study

The HOME Study

UniCog: A Novel Online Neuropsychological Battery for Diverse Populations

Severe Mental Illness Longitudinal Evaluation (SMILE) BioResource

AMON-ANWAR: Advancing our understanding of Multiscale Organization in Neuroscience: Arbor as key eNabler of Workflows at exascAle in brain Research